PRP, PRF, & PRFM: Current Research & Uses

Platelet-rich plasma contains an abundance of growth factors and cytokines that affect inflammation, fibroblast proliferation and migration, collagen synthesis and proliferation, angiogenesis, stem cell migration, and differentiation of numerous cell types.

A review of the safety of PRP, PRF, and PRMF in medical research shows that it has been safely used in:

• Oral and Maxillofacial Surgery, Dentistry, Periodontology, Endodontics

• Bone Regeneration

• Wound Healing

• Cartilage regeneration and osteoarthritis

• Dermatology

  • Androgenetic Alopecia

    • Hair Restoration

• Acne Scarring

• Skin Rejuvenation

  • Skin tightening

  • Improve fine lines and deep lines

  • Improved skin texture and quality

  • Improved pigmentation and brightening

  • Collagen stimulation

The use of platelet-rich fibrin (PRF) has seen widespread advantages over platelet-rich plasma (PRP) in many fields of medicine. PRF achieves even better results than PRP because it contains 8 to 10 times more growth factors than PRP and releases growth factors slowly for more prolonged effects. PRFM is a more advanced version of PRP, enhancing the benefits and improving results.

PRFM is created using a slower centrifuge, which better preserves the cells and growth factors and creates a “scaffolding” allowing the age-defying growth factors to remain in the tissues for seven days or more. PRFM also more closely parallels the body’s innate wound response, forming a cross-linked fibrin matrix that serves as a binding site and allows for an increased concentration of growth factors at the targeted site to guide collagen deposition.

Despite the appeal of PRFM’s relative noninvasiveness, well-established safety profile, and scientific mechanism of action, PRRM used in aesthetic settings is not an FDA-approved treatment.