PRP vs PRF vs PRFM: What is the Difference?

Jun 19

Written By Sheri Rocha

PRP (Platelet-rich Plasma):

First Generation: the original breakthrough; widely used in the early 2000s
Utilizes concentrated plasma rich in growth factors to stimulate tissue healing.
Concentrated platelets release growth factors that initiate the body’s natural wound-healing process and promote cell proliferation, collagen production, and blood vessel formation, enhancing tissue repair support.
PRP has shown promising results in various medical fields. It can accelerate the wound healing process, reduce pain and inflammation, and improve tissue function.

PRF (Platelet-rich Fibrin):

Second Generation: widely used in late 2000s and early 2010s
PRF is similar to PRP, however the processing method differs resulting in a fibrin clot that contains platelets.
Growth factors are released in a sustained manner through a fibrin matrix increasing its duration of effects.
PRF has been widely used in dentistry, oral and maxillofacial surgery, and plastic and reconstructive surgery. It promotes soft tissue grafting, wound healing, bone healing, and periodontal healing among other applications.

PRFM (Platelet-rich Fibrin Matrix):

Third Generation: the most recent development; gained popularity in 2010s
Combines the benefits of PRP and PRF with a processing method that results in a scaffold-like, spongy fibrin matrix to protect and retain concentrated platelets and growth factors.
The matrix provides a sustained release of growth factors and offers a supportive structure for cells
PRFM has found applications in aesthetics, dermatology, and plastic surgery. It can be incorporated into facial treatments (vampire facials), reduce fine lines and wrinkles, and enhance wound healing.

PRP, PRF, and PRFM therapies primarily utilize platelets derived from the patient's own blood. Platelets contain growth factors that promote tissue healing and stimulate cell function with minimal side effects. While these therapies share similarities, their concentrations, duration of effect, and applications differ.