Exploring the brands of Botulinum Toxin Type A
With botulinum toxins, there are several brands to choose from. I often get asked “Which brand is better?” and it is all dependent on the person.
Some brands seem to work better on specific individuals, so I recommend trying them out to see where your preference lies. The main difference in these products is their purification manufacturing processes – some items contain accessory proteins and/or albumin. They are all working towards the same end goal.
Botox (onabotulinumtoxinA)
Manufacturer: Allergan Aesthetics, an AbbVie company. Ireland.
FDA Approved: 2002
Original most well-known brand with a long history of clinical use and research backing its efficacy and safety.
Prepared using a complex purification process which results in a complex containing toxins and other proteins which is then freeze-dried and sealed.
Dysport (abobotulinumtoxinA)
Manufacturer: Galderma. United Kingdom.
FDA Approved: 2009
Slightly different formulation that may spread more widely
Prepared using purification techniques which is then freeze-dried and sealed.
Xeomin (incobotulinumtoxinA)
Manufacturer: Merz Pharmaceuticals. Germany.
FDA Approved: 2011
Pure form of botulinum toxin
Prepared using extensive purification process XTRACT which removes complex proteins and contains only active components which are then freeze-dried and sealed.
Jeuveau (prabotulinumtoxinA)
Manufacturer: Evolus, South Korea.
FDA Approved: 2019
Newer option, but inconsistent results for some patients
Prepared using Hi-Pure technology purification process to obtain >95% pure components which is then freeze-dried and sealed.
Daxxify (daxibotulinumtoxinA)
Manufacturer: Revance Therapeutics, United States of America.
FDA Approved: 2022
First peptide-formulated, long-acting botulinum toxin; median duration of 6 months.
Peptide aids in both the stability and delivery of toxin. No accessory proteins, no albumin, no animal derivates.